On macOS, there is no exact Ctrl+Alt+Delete shortcut, but the equivalent for force-quitting unresponsive apps is Command+Option+Escape. This instantly opens the Force Quit Applications window for quick termination.
Quick Force Quit with Command+Option+Escape
Press Command (⌘) + Option (⌥) + Escape (⎋) simultaneously when an app freezes. This brings up a dialog listing running apps:
- Select the problematic application.
- Click "Force Quit" to close it immediately.
Use this method for non-responsive software to regain control without restarting your Mac.

Alternative Approach: Activity Monitor
For advanced troubleshooting, Activity Monitor serves as the macOS task manager. Access it via Spotlight: press Command+Space, type "Activity Monitor," and hit Enter. Then:
- Locate the unresponsive app in the process list.
- Select it and click the stop icon (ⓧ) in the toolbar.
- Choose "Force Quit" to confirm.
This method provides real-time CPU and memory monitoring, ideal for persistent issues.
Fallback Option: Apple Menu Force Quit
If keyboard shortcuts fail, go to the top-left Apple menu and select "Force Quit" from the dropdown. This opens the same window as Command+Option+Escape, allowing app selection and termination.
Reserve force quitting for emergencies; always save work to prevent data loss from abrupt closures.